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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.L180M+rt.M204I+rt.T184A;rt.L180M+rt.M204I+rt.M204V+rt.T184A;rt.L180M+rt.M204I+rt.T184L;rt.L180M+rt.M204I+rt.M204V+rt.T184L;rt.L180M+rt.M204I+rt.M204V+rt.T184L+rt.T184A;rt.L180M+rt.M204I+rt.T184S;rt.L180M+rt.M204I+rt.M204V+rt.T184S;rt.L180M+rt.M204I+rt.T184S+rt.T184A;rt.L180M+rt.M204I+rt.T184I;rt.M204I+rt.T184I;rt.L180M+rt.M204I+rt.M204V+rt.T184I;rt.M204I+rt.M204V+rt.T184I;rt.L180M+rt.M204I+rt.S202G;rt.L180M+rt.M204I+rt.M204V+rt.S202G;rt.L180M+rt.M204I+rt.M250V;rt.L180M+rt.M204I+rt.M204V+rt.M250V;rt.L180M+rt.M204I+rt.M250L;rt.L180M+rt.M204I+rt.M204V+rt.M250L;rt.L180M+rt.M204I+rt.M250I;rt.L180M+rt.M204I+rt.M204V+rt.M250I;rt.L180M+rt.M204I+rt.M204V+rt.M250L+rt.M250V |
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Relevant Drug
|
entecavir (ETV) |
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Country
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China |
Literature Information
|
PubMed PMID
|
30866789
|
|
Disease
|
HBV infection
|
|
Published Year
|
2019 |
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Journal
|
Emerging microbes & infections |
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Title
|
Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice. |
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Author
|
Liu Y,Zhou Y,Li X,Niu M,Chen R,Shao J,Si L,Luo D,Lin Y,Li L,Zhang K,Xiao X,Xu Z,Liu M,Lu M,Zoulim F,Xu D |
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Evidence
|
Entecavir (ETV) resistance of hepatitis B virus (HBV) conventionally requires rt184, 202, or 250 mutations plus lamivudine-resistance mutation (rtM204V/I +- L180M).
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|
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HBV Mutation Detail Information