|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.M204I |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15280461
|
|
Published Year
|
2004 |
|
Journal
|
Journal of virology |
|
Title
|
Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants. |
|
Author
|
Tacke F,Gehrke C,Luedde T,Heim A,Manns MP,Trautwein C |
|
Evidence
|
Treatment of chronic HBV infection with lamivudine (LMV) often selects drug-resistant strains with single (rtM204I) or double (rtL180M+rtM204V) point mutations in the YMDD motif of HBV reverse transcriptase.
|
|
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HBV Mutation Detail Information