|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V;rt.V173L+rt.M204V;rt.V173L+rt.L180M+rt.M204V |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
16378967
|
|
Disease
|
HBV infection
|
|
Published Year
|
2006 |
|
Journal
|
Journal of virology |
|
Title
|
Dynamics of hepatitis B virus resistance to lamivudine. |
|
Author
|
Pallier C,Castéra L,Soulier A,Hézode C,Nordmann P,Dhumeaux D,Pawlotsky JM |
|
Evidence
|
Virological breakthrough was preceded by 2 to 4 months by the emergence of quasispecies variants bearing amino acid substitutions at RT position 204, i.e., within the YMDD catalytic motif (rtM204V/I).
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HBV Mutation Detail Information