|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L80I+rt.L80V+rt.M204V;rt.L180M+rt.M204V;rt.L180M+rt.L80I+rt.L80V+rt.M204V |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
17438047
|
|
Published Year
|
2007 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro. |
|
Author
|
Warner N,Locarnini S,Kuiper M,Bartholomeusz A,Ayres A,Yuen L,Shaw T |
|
Evidence
|
Coselection of rtL80V/I occurred in 46% of isolates in which LMV resistance was attributable to rtM204I but only 9% of those in which resistance was attributable to rtM204V.
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|
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HBV Mutation Detail Information