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Mutation Information
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Mutation Site
|
M204V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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lamivudine (LAM);telbivudine (LDT);clevudine (CLV);entecavir (ETV) |
Literature Information
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PubMed PMID
|
19669299
|
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Published Year
|
2008 |
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Journal
|
Hepatology international |
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Title
|
Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure. |
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Author
|
Locarnini S |
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Evidence
|
The rtM204V/I pathway is responsible for resistance to the L: -nucleosides, such as lamivudine (LMV), telbivudine (LdT) and clevudine (CLD), and also entecavir (ETV), whilst the rtN236T pathway is responsible for adefovir (ADV) and tenofovir (TFV) resistance.
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HBV Mutation Detail Information