|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30586543
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2018 |
|
Journal
|
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases |
|
Title
|
Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model. |
|
Author
|
Zhang J,Wang Y,Peng Y,Qin C,Liu Y,Li J,Jiang J,Zhou Y,Chang J,Wang Q |
|
Evidence
|
We generated a stable cell line encoding the major pattern of lamivudine-resistant mutations rtL180M/M204V and designated it "HepG2.RL1”.
|
|
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HBV Mutation Detail Information