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Mutation Information
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Mutation Site
|
M250L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A;B;C;D |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Canada;Italy;China;United States |
Literature Information
|
PubMed PMID
|
29713126
|
|
Published Year
|
2018 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. |
|
Author
|
Choi YM,Lee SY,Kim BJ |
|
Evidence
|
Of these, 10 patients had mutations associated with primary resistance or reduced sensitivity, including three cases with a YMDD mutation (rtM204V), three with the mutation, rtM250L/V, which is associated with ETV resistance, and four with the mutation rtI233V, which is associated with reduced sensitivity to ADV.
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HBV Mutation Detail Information