|
Mutation Information
|
Mutation Site
|
M250L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
E |
|
Relevant Drug
|
tenofovir (TDF);entecavir (ETV) |
|
Country
|
France |
Literature Information
|
PubMed PMID
|
32735901
|
|
Disease
|
HBV infection
|
|
Published Year
|
2020 |
|
Journal
|
Antiviral research |
|
Title
|
Revisiting HBV resistance to entecavir with a phenotypic approach. |
|
Author
|
Marlet J,Lier C,Roch E,Maugey M,Moreau A,Combe B,Lefeuvre S,d'Alteroche L,Barbereau D,Causse X,Bastides F,Bachelier MN,Brand D,Gaudy-Graffin C |
|
Evidence
|
Reversion to wild-type amino acid at this position partially restored susceptibility to entecavir, confirming that the rt250L mutation was responsible for the high level of resistance to entecavir.
|
|
|
HBV Mutation Detail Information