|
Mutation Information
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Mutation Site
|
M539I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10091998
|
|
Published Year
|
1999 |
|
Journal
|
The Journal of general virology |
|
Title
|
Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus. |
|
Author
|
Ling R,Harrison TJ |
|
Evidence
|
The M539I substitution in the conserved YMDD motif occurs independently of other changes, whereas the M539V substitution is associated with an additional upstream change (L515M).
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HBV Mutation Detail Information