|
Mutation Information
|
Mutation Site
|
M550I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Combined Mutation
|
p.M550I+p.L526M+p.V519L |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10669360
|
|
Disease
|
HBV infection
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy. |
|
Author
|
Mutimer D,Pillay D,Cook P,Ratcliffe D,O'Donnell K,Dowling D,Shaw J,Elias E,Cane PA |
|
Evidence
|
Hepatitis B virus (HBV) drug resistance to lamivudine is always accompanied by mutations in the viral polymerase gene at position 550, termed group 1 (M550V with L526M) or group 2 (M550I) mutations.
|
|
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HBV Mutation Detail Information