|
Mutation Information
|
Mutation Site
|
M550I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
famciclovir (FCV);lamivudine (LAM) |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
11792996
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2002 |
|
Journal
|
Transplantation |
|
Title
|
Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant. |
|
Author
|
Tang S,Ho SK,Moniri K,Lai KN,Chan TM |
|
Evidence
|
The severe hepatitic flare consequent to the lamivudine resistance in this patient was successfully treated with famciclovir, indicating that both M550V and M550I mutants with preserved wild-type sequence at position 526 of HBV reverse transcriptase are susceptible to famciclovir.
|
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HBV Mutation Detail Information