|
Mutation Information
|
Mutation Site
|
M550I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
9824278
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
1998 |
|
Journal
|
Journal of hepatology |
|
Title
|
The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss. |
|
Author
|
de Man RA,Bartholomeusz AI,Niesters HG,Zondervan PE,Locarnini SA |
|
Evidence
|
Three amino acid changes were selected while the patient was on lamivudine treatment, which include L533I, S559T and M550I.
|
|
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HBV Mutation Detail Information