|
Mutation Information
|
Mutation Site
|
M550V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Combined Mutation
|
p.M550V+p.L526M+p.V519L |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10669360
|
|
Disease
|
HBV infection
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy. |
|
Author
|
Mutimer D,Pillay D,Cook P,Ratcliffe D,O'Donnell K,Dowling D,Shaw J,Elias E,Cane PA |
|
Evidence
|
After addition of famciclovir, population sequencing showed that the predominant species was V519L/L526M/M550V and that the level of isoleucine at position 550 and leucine at position 526 had declined markedly.
|
|
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HBV Mutation Detail Information