HBV Mutation Detail Information

> M552I Search Result

Mutation Information

Mutation Site	M552I
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	11584376
Disease	Chronic hepatitis B
Published Year	2001
Journal	Hepatology (Baltimore, Md.)
Title	Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy.
Author	Yuen MF,Sablon E,Hui CK,Yuan HJ,Decraemer H,Lai CL
Evidence	Patients with HBV DNA breakthroughs had higher percentages of YMDD variants without the presence of wild-type YMDD compared with patients without HBV DNA breakthrough (25.6% vs. 9%, P =.007 for single M552I variant; 20.9% vs. 8.1%, P =.026 for single M552V variant; 30.2% vs. 9.9%, P =.004 for M552I/M552V variants).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation