|
Mutation Information
|
Mutation Site
|
M552I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
12823594
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2003 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Analysis of clinical, biochemical and viral factors associated with early relapse after lamivudine treatment for hepatitis B e antigen-negative chronic hepatitis B patients in Taiwan. |
|
Author
|
Huang YH,Wu JC,Chang TT,Sheen IJ,Lee PC,Huo TI,Su CW,Wang YJ,Chang FY,Lee SD |
|
Evidence
|
Sequencing of the polymerase region during breakthrough revealed a methionine to isoleucine mutation at codon 552.
|
|
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HBV Mutation Detail Information