HBV Mutation Detail Information

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Mutation Information

Mutation Site	M552V
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM);emtricitabine (FTC)

Literature Information

PubMed PMID	11312349
Published Year	2001
Journal	Journal of virology
Title	Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).
Author	Das K,Xiong X,Yang H,Westland CE,Gibbs CS,Sarafianos SG,Arnold E
Evidence	The predominant lamivudine resistance mutations in HBV-infected patients are Met552IIe and Met552Val (Met552Ile/Val), frequently in association with a second mutation, Leu528Met.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation