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Mutation Information
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Mutation Site
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N140T |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp41 |
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Country
|
Spain |
Literature Information
|
PubMed PMID
|
22333046
|
|
Clinical information
|
Yes
|
|
Disease
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HIV infection/AIDS
|
|
Published Year
|
2012 |
|
Journal
|
Retrovirology |
|
Title
|
The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype. |
|
Author
|
Cunyat F,Marfil S,García E,Svicher V,Pérez-Alvárez N,Curriu M,Perno CF,Clotet B,Blanco J,Cabrera C |
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Evidence
|
When an inter-patient comparison was performed by grouping all of the Envs obtained from each patient irrespective of the time point, a significantly different percentage of Env-expressing cells was observed between plasmids constructed from the 140N- and N140T-carrying patients.
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HIV Mutation Detail Information