|
Mutation Information
|
Mutation Site
|
N146S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.G130R+s.C124N+s.N146S |
|
Viral Reference
|
D00630;
M54923;
HPBAYW |
|
Immune Escape
|
Y |
|
Relevant Drug
|
fludarabine |
|
Country
|
Greek |
Literature Information
|
PubMed PMID
|
16789016
|
|
Disease
|
HBV infection
|
|
Published Year
|
2006 |
|
Journal
|
Journal of medical virology |
|
Title
|
Detection of a hepatitis B surface antigen variant emerging in a patient with chronic lymphocytic leukaemia treated with fludarabine. |
|
Author
|
Alexopoulou A,Dourakis SP,Pandelidaki H,Archimandritis AJ,Karayiannis P |
|
Evidence
|
Amino-acid sequence comparisons over the alpha determinant region revealed the following substitutions: C124N, G130R, and N146S.
|
|
|
HBV Mutation Detail Information