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Mutation Information
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Mutation Site
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N155H |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
Literature Information
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PubMed PMID
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31120420
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Published Year
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2019 |
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Journal
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eLife |
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Title
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HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. |
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Author
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Koneru PC,Francis AC,Deng N,Rebensburg SV,Hoyte AC,Lindenberger J,Adu-Ampratwum D,Larue RC,Wempe MF,Engelman AN,Lyumkis D,Fuchs JR,Levy RM,Melikyan GB,Kvaratskhelia M |
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Evidence
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For example, a recent clinical study revealed that failure of DTG treatment in patients was observed with concomitant appearance of IN N155H/K211R/E212T substitutions on the background of the K156N polymorphic mutation .
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HIV Mutation Detail Information