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Mutation Information
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Mutation Site
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N155H |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Combined Mutation
|
in.Q148H+in.N155H |
Literature Information
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PubMed PMID
|
32974383
|
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Published Year
|
2020 |
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Journal
|
Frontiers in molecular biosciences |
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Title
|
Evidence for Disruption of Mg2+ Pair as a Resistance Mechanism Against HIV-1 Integrase Strand Transfer Inhibitors. |
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Author
|
Machado LA,Guimarães ACR |
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Evidence
|
While some resistance-related mutations occur near the inhibitor's binding site, the mutation N155H occurs on the opposite side of the drug-interacting Mg(2+) ions, thus, not interacting directly with the drug molecules and currently lacking an explanation for its resistance mechanism.
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HIV Mutation Detail Information