|
Mutation Information
|
Mutation Site
|
N222K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
Literature Information
|
PubMed PMID
|
31120420
|
|
Published Year
|
2019 |
|
Journal
|
eLife |
|
Title
|
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. |
|
Author
|
Koneru PC,Francis AC,Deng N,Rebensburg SV,Hoyte AC,Lindenberger J,Adu-Ampratwum D,Larue RC,Wempe MF,Engelman AN,Lyumkis D,Fuchs JR,Levy RM,Melikyan GB,Kvaratskhelia M |
|
Evidence
|
The control N222K substitution in the CCD-CTD connecting alpha-helix formed tetramers, retained WT levels of HIV-1 replication in cell culture, IN catalytic activity and LEDGF/p75 binding in vitro, and was fully susceptible to both KF116 and BI224436 induced higher-order IN multimerization (Figure 4 and Figure 4:figure supplements 1-4).
|
|
|
HIV Mutation Detail Information