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Mutation Information
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Mutation Site
|
N236T |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir (ADV) |
Literature Information
|
PubMed PMID
|
15261293
|
|
Published Year
|
2004 |
|
Journal
|
Bioorganic & medicinal chemistry letters |
|
Title
|
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study. |
|
Author
|
Yadav V,Chu CK |
|
Evidence
|
In the case of rtN236T mutant, loss of two hydrogen bonds accompanied by significant decrease in electrostatic interactions is observed, which explains the observed decrease in drug sensitivity and binding affinity of adefovir diphosphate toward the rtN236T mutant HBV polymerase.
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HBV Mutation Detail Information