HBV Mutation Detail Information

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Mutation Information

Mutation Site	N236T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Viral Reference	X70185
Relevant Drug	adefovir (ADV)
Country	China

Literature Information

PubMed PMID	17913933
Disease	Chronic hepatitis B
Published Year	2007
Journal	Journal of clinical microbiology
Title	Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
Author	Libbrecht E,Doutreloigne J,Van De Velde H,Yuen MF,Lai CL,Shapiro F,Sablon E
Evidence	On the basis of the LiPA results, six patients showed a transient emergence of adefovir-resistant mutants (rtA181T or rtN236T), while nine patients had adefovir-resistant mutants that persisted for several weeks, of whom eight had mutants with the rtA181T mutation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation