|
Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir dipivoxil (ADV) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
24696492
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Journal of virology |
|
Title
|
The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene. |
|
Author
|
Ahn SH,Park YK,Park ES,Kim JH,Kim DH,Lim KH,Jang MS,Choe WH,Ko SY,Sung IK,Kwon SY,Kim KH |
|
Evidence
|
Clonal analyses revealed that the mutants containing rtH55R+I233V+N236T emerged and were dominantly selected during ADV treatment failure (the “10 series”).
|
|
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HBV Mutation Detail Information