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Mutation Information
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Mutation Site
|
N236T |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.N236T+rt.A181S |
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Genotype/Subtype
|
B;C |
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Relevant Drug
|
adefovir (ADV);adefovir dipivoxil (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
25132017
|
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Disease
|
HBV infection
|
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Published Year
|
2015 |
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Journal
|
Journal of viral hepatitis |
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Title
|
The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil. |
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Author
|
Liu Y,Li X,Xin S,Xu Z,Chen R,Yang J,Liu L,Wong VW,Yang D,Chan HL,Xu D |
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Evidence
|
Phenotypic analysis of patient-derived viral strains showed that rtA181S, rtA181S+N236T, rtN236T and rtA181V strains had 68.5%, 49.9%, 71.4% and 66.2% of natural replication capacity of wild-type strain, and 3.7-fold, 9.8-fold, 7.9-fold and 5.6-fold increased EC(50) to adefovir dipivoxil (ADV).
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HBV Mutation Detail Information