|
Mutation Information
|
Mutation Site
|
N238T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
adefovir dipivoxil (ADV) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
25303802
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Antiviral research |
|
Title
|
Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B. |
|
Author
|
Cho YK,Cui XJ,Jeong SU,Song BC |
|
Evidence
|
During ADV therapy, ADV resistance occurred in 9 patients. All of these harbored ADV-resistant mutants (rtA181V/T, n = 2; rtN236T, n = 2; rtA181V/T and rtN236T, n = 4; rtA181V/T and rtN238T, n = 1).
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HBV Mutation Detail Information