|
Mutation Information
|
Mutation Site
|
N265D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
RT1t49 |
Literature Information
|
PubMed PMID
|
17644816
|
|
Published Year
|
2007 |
|
Journal
|
Nucleic acids research |
|
Title
|
Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers. |
|
Author
|
Kissel JD,Held DM,Hardy RW,Burke DH |
|
Evidence
|
Further modeling suggests RT1t49-resistant mutations N255D and N265D would be in direct contact with nucleotides 27 and 5, respectively, and place these amino acids in a position to influence interactions with RT1t49.
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|
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HIV Mutation Detail Information