HIV Mutation Detail Information

> N280D Search Result

Mutation Information

Mutation Site	N280D
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env

Literature Information

PubMed PMID	31527908
Published Year	2019
Journal	PLoS pathogens
Title	Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
Author	LaBranche CC,Henderson R,Hsu A,Behrens S,Chen X,Zhou T,Wiehe K,Saunders KO,Alam SM,Bonsignori M,Borgnia MJ,Sattentau QJ,Eaton A,Greene K,Gao H,Liao HX,Williams WB,Peacock J,Tang H,Perez LG,Edwards RJ,Kepler TB,Korber BT,Kwong PD,Mascola JR,Acharya P,Haynes BF,Montefiori DC
Evidence	G458Y/GnT1- is predicted to be highly sensitive for detecting vaccine-elicited early precursors of the CH235/CH235.12 lineage, where samples testing positive may be assayed against the N280D knock-out to confirm CD4bs-specificity (Fig 1, S1H and S1I Fig).testing positive may be assayed against the N280D knock-out to confirm CD4bs-specificity (Fig 1, S1H and S1I Fig).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation