HIV Mutation Detail Information

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Mutation Information

Mutation Site	N300A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Combined Mutation	env.N300A+env.K305A
Genotype/Subtype	B
Immune Escape	Y

Literature Information

PubMed PMID	30538178
Published Year	2018
Journal	mBio
Title	Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.
Author	Guzzo C,Zhang P,Liu Q,Kwon AL,Uddin F,Wells AI,Schmeisser H,Cimbro R,Huang J,Doria-Rose N,Schmidt SD,Dolan MA,Connors M,Mascola JR,Lusso P
Evidence	Both the N300A and the K305A mutants exhibited a neutralization profile similar to that of V2 loop tyrosine mutants, with increased sensitivity to sCD4 and weakly neutralizing antibodies 412d and 447-52D, while conversely showing decreased sensitivity to the trimer-preferring bNAb PG9; in contrast, mutation of N302 or R304 did not significantly alter the neutralization profile (Fig. 4).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation