HIV Mutation Detail Information

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Mutation Information

Mutation Site	N301A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Genotype/Subtype	C
Viral Reference	K03455.1
Immune Escape	Y
Relevant Drug	VRC01 class of broadly neutralising antibodies

Literature Information

PubMed PMID	30302011
Published Year	2018
Journal	Scientific reports
Title	Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan.
Author	Ferreira RC,Grant OC,Moyo T,Dorfman JR,Woods RJ,Travers SA,Wood NT
Evidence	We examined a naturally occurring subtype C isolate and its N301A mutant;the mutant not only remained protected against neutralising antibodies targeting underlying epitopes, but also exhibited an increased resistance to the VRC01 class of broadly neutralising antibodies.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation