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Mutation Information
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Mutation Site
|
N425G |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
Literature Information
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PubMed PMID
|
33466381
|
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Published Year
|
2021 |
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Journal
|
Molecules (Basel, Switzerland) |
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Title
|
Does Antibody Stabilize the Ligand Binding in GP120 of HIV-1 Envelope Protein? Evidence from MD Simulation. |
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Author
|
Yadav S,Pandey V,Kumar Tiwari R,Ojha RP,Dubey KD |
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Evidence
|
We have found that the N425G mutation increases the binding affinity but it does not induce the flexibility in gp120 due to a lack of flexible side chain interaction with NBD-557.
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HIV Mutation Detail Information