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Evidence
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May create immune escape mutants leading to chronic viral persistence and severe liver disease Point mutations between aa 74-89 May reduce both HBe and HBc antigenicity proline replacing a serine at 181 Frequent in patients of HCC or ESLD P130T mutation with a mutation at codon 197L It enables HBV to secrete excessive amounts of virions containing incomplete single-stranded DNA P protein Change of methionine to valine or isoleucine in YMDD motif Associated with resistance to lamivudine therapy aa substitutions, Leu-568 to Val, Ser-561 to Thr, lle-511 to Val, Ala-548 to Val, Ser-567 to Ala, Ala-570 to Thr or Val 521 to Leu and Leu-528 to Met These mutations may cause resistance to lamivudine and famciclovir.
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HBV Mutation Detail Information