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Mutation Information
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Mutation Site
|
P177S |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.S202G+rt.L180M+rt.P177S+rt.V173L |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
17239478
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
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Published Year
|
2007 |
|
Journal
|
Journal of hepatology |
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Title
|
Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. |
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Author
|
Villet S,Ollivet A,Pichoud C,Barraud L,Villeneuve JP,Trépo C,Zoulim F |
|
Evidence
|
The addition of the rtA181G change to this triple mutant resulted in a 1.5-fold replication impairment, whereas the addition of rtI169L and rtV173L+P177S increased by 1.3- and 1.8-fold, respectively, the replication capacity of the same triple mutant. The rtV173L+P177S+L180M+S202G+M204V mutant even showed an increased replication efficiency (by 1.3-fold) compared to wt HBV.
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HBV Mutation Detail Information