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Mutation Information
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Mutation Site
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P203L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
Literature Information
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PubMed PMID
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33515546
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Published Year
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2021 |
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Journal
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The Journal of biological chemistry |
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Title
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Ceramide synthase 2 deletion decreases the infectivity of HIV-1. |
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Author
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Barklis E,Alfadhli A,Kyle JE,Bramer LM,Bloodsworth KJ,Barklis RL,Leier HC,Petty RM,Zelnik ID,Metz TO,Futerman AH,Tafesse FG |
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Evidence
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We also tested two additional HIV-1 Env CT mutants: one of these was an Env P714L mutant (also called P203L) that was selected for resistance to cholesterol depletion; and the other was the Env 716Ins-R* mutant, which is cleaved by the HIV-1 protease (PR) in a similar fashion to P714L.
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HIV Mutation Detail Information