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HBV Mutation Detail Information

> P25G Search Result


Mutation Information
Mutation Site P25G
Mutation Type Amino acid level
Gene/Protein/Region Type C
Literature Information
PubMed PMID 28205569
Published Year 2017
Journal Scientific reports
Title Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Author Zhou Z,Hu T,Zhou X,Wildum S,Garcia-Alcalde F,Xu Z,Wu D,Mao Y,Tian X,Zhou Y,Shen F,Zhang Z,Tang G,Najera I,Yang G,Shen HC,Young JA,Qin N
Evidence In contrast, T33S mutant only shows a 2-fold increase. On the basis of the similar rationale, P25G mutant decreases the sensitivity to both SBA and HAP to different levels (12 to more than 67 fold EC50 increase).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation