HIV Mutation Detail Information

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Mutation Information

Mutation Site	P308T
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	21356539
Published Year	2011
Journal	Virology
Title	Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.
Author	Anastassopoulou CG,Ketas TJ,Depetris RS,Thomas AM,Klasse PJ,Moore JP
Evidence	Of note is that the resistance-relevant proline at residue 308 was absent from the reversion isolates, and although a change arose at this position, it was not to the dominant parental histidine, but to a new amino acid, threonine (i.e., P308T).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation