|
Mutation Information
|
Mutation Site
|
P5T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
30902704
|
|
Published Year
|
2019 |
|
Journal
|
Antiviral research |
|
Title
|
Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate. |
|
Author
|
Zhang Y,Zhang H,Zhang J,Zhang J,Guo H |
|
Evidence
|
Further mutagenesis study revealed that the P5T mutation of core protein plays an important role in the enhanced viral replication through increasing the levels of capsid formation and pregenomic RNA encapsidation.
|
|
|
HBV Mutation Detail Information