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Mutation Information
|
Mutation Site
|
P90A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
CA |
|
Relevant Drug
|
IFN-beta |
Literature Information
|
PubMed PMID
|
31511380
|
|
Published Year
|
2019 |
|
Journal
|
Journal of virology |
|
Title
|
Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid. |
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Author
|
Sultana T,Mamede JI,Saito A,Ode H,Nohata K,Cohen R,Nakayama EE,Iwatani Y,Yamashita M,Hope TJ,Shioda T |
|
Evidence
|
We first examined the IFN-beta sensitivity of the RGDA/Q112D virus, since the P90A mutation in CA, which results in a CypA binding-deficient mutant, has been shown to increase the sensitivity to IFN-alpha-mediated inhibition.
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HIV Mutation Detail Information