HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q151M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B;C
Relevant Drug	NRTIs;tenofovir (TDF)
Country	Zambia

Literature Information

PubMed PMID	21569325
Disease	HIV infection/AIDS
Published Year	2011
Journal	Retrovirology
Title	The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains.
Author	Mbisa JL,Gupta RK,Kabamba D,Mulenga V,Kalumbi M,Chintu C,Parry CM,Gibb DM,Walker SA,Cane PA,Pillay D
Evidence	The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domainsThe Q151M multi-drug resistance (MDR) pathway in HIV-1 reverse transcriptase (RT) confers reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation