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Mutation Information
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Mutation Site
|
Q563A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
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Gp41 |
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Genotype/Subtype
|
B |
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Immune Escape
|
Y |
Literature Information
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PubMed PMID
|
32392227
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
|
PLoS pathogens |
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Title
|
Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. |
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Author
|
Joshi VR,Newman RM,Pack ML,Power KA,Munro JB,Okawa K,Madani N,Sodroski JG,Schmidt AG,Allen TM |
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Evidence
|
To test whether arginine at position 563 was specifically critical for this phenotype, we changed this residue in both Env E1 and NE1 to alanine (E1 Q563A and NE1 Q563A, respectively).
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HIV Mutation Detail Information