HIV Mutation Detail Information

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Mutation Information

Mutation Site	Q577A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp41

Literature Information

PubMed PMID	33041100
Published Year	2020
Journal	Vaccine
Title	DNA adjuvant Amiloride conjunct long immunization interval promote higher antibody responses to HIV-1 gp41 and gp140 immunogens.
Author	Yao L,Wang JY,Bao LN,Fan MX,Bai Y,Chen WJ,Yuan C,Yuan L,Wang J,Li Y,Zhuang M,Ling H
Evidence	Q577A mutant was benefit for trimeric gp140 boost in the production of binding Abs but harmful to inducing neutralizing Abs, while this mutant in monomeric gp41 presented the opposite trend which may be associated with the immunogen structures.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation