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Mutation Information
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Mutation Site
|
Q62R |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gag |
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Viral Reference
|
AF038399.1
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Literature Information
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PubMed PMID
|
32272714
|
|
Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
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Title
|
Recent Advances in HIV-1 Gag Inhibitor Design and Development. |
|
Author
|
Dick A,Cocklin S |
|
Evidence
|
Consequently, the stabilization of the MA trimers by introducing a glutaraldehyde crosslinking approach at Ser66 and Gln62 or introducing a Gln62Arg mutation in the trimer interface (Gln62 represented as orange and Ser 66 as yellow spheres in Figure 6) increased Env-CT binding (in a pool down assay) and highlighted the importance of MA trimers for gp41-CT recognition.
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HIV Mutation Detail Information