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Mutation Information
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Mutation Site
|
Q65R |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
Literature Information
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PubMed PMID
|
32538781
|
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Published Year
|
2020 |
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Journal
|
eLife |
|
Title
|
HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. |
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Author
|
Zhang F,Bieniasz PD |
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Evidence
|
The effect of Vpr on HIV-1 gene expression was more pronounced in primary macrophages, where V1/HA-Vpr but not V1/HA-Vpr(Q65R) resulted in higher levels of GFP expression than did infection with V1/δ-Vpr, even though marked donor-to-donor variation was evident.
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HIV Mutation Detail Information