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Mutation Information
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Mutation Site
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R118G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
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32538781
|
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Published Year
|
2020 |
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Journal
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eLife |
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Title
|
HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. |
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Author
|
Zhang F,Bieniasz PD |
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Evidence
|
When the biotinylation proximity assay (Roux et al., 2012) was coupled to Western blot analysis, CCDC137 was found to be biotinylated by Vpr-BirA(R118G) but not BirA(R118G) despite our inability to detect biotinylated CCDC137 in the initial mass spectroscopic screens (Figure 3C).
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HIV Mutation Detail Information