HIV Mutation Detail Information

> R228A Search Result

Mutation Information

Mutation Site	R228A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	32960169
Published Year	2020
Journal	eLife
Title	Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Author	Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB
Evidence	Second, the R228A substitution abolished full-length IN in virions without impacting cell- or virion-associated Gag-Pol levels or processing intermediates;however, a faster migrating species generated by aberrant IN processing and/or IN degradation was visible.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation