HIV Mutation Detail Information

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Mutation Information

Mutation Site	R263K
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Genotype/Subtype	D
Relevant Drug	INSTIs

Literature Information

PubMed PMID	30648124
Disease	HIV infection/AIDS
Published Year	2019
Journal	Open forum infectious diseases
Title	Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.
Author	Ahmed N,Flavell S,Ferns B,Frampton D,Edwards SG,Miller RF,Grant P,Nastouli E,Gupta RK
Evidence	Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug ResistanceDolutegravir (DTG), a second-generation integrase strand-transfer inhibitor (INSTI), is equivalent or superior to current non-nucleotide reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and first-generation INSTI-based antiretroviral regimens (ARVs).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation