|
Mutation Information
|
Mutation Site
|
R264K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
|
Combined Mutation
|
ca.R264K+ca.L268M;ca.R264K+ca.R286K+ca.T280S |
|
Genotype/Subtype
|
B |
|
Immune Escape
|
Y |
Literature Information
|
PubMed PMID
|
11157057
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2001 |
|
Journal
|
The Journal of experimental medicine |
|
Title
|
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. |
|
Author
|
Kelleher AD,Long C,Holmes EC,Allen RL,Wilson J,Conlon C,Workman C,Shaunak S,Olson K,Goulder P,Brander C,Ogg G,Sullivan JS,Dyer W,Jones I,McMichael AJ,Rowland-Jones S,Phillips RE |
|
Evidence
|
Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.
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HIV Mutation Detail Information