|
Mutation Information
|
Mutation Site
|
R269K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
CRF02_AG |
|
Relevant Drug
|
bictegravir (BIC);dolutegravir (DTG) |
|
Country
|
Africa |
Literature Information
|
PubMed PMID
|
31830799
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and human retroviruses |
|
Title
|
HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon. |
|
Author
|
Mikasi SG,Gichana JO,Van der Walt C,Brado D,Obasa AE,Njenda D,Messembe M,Lyonga E,Assoumou O,Cloete R,Ikomey GM,Jacobs GB |
|
Evidence
|
Therefore, these polymorphisms (VI72IV and R269K) in our study indicated that they are significantly enriched in RAL-treated patients infected with the HIV-1 CRF02_AG subtype compared with INSTI-naive patients and may thus influence the evolution of DTG resistance
|
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HIV Mutation Detail Information