HIV Mutation Detail Information

> R277K Search Result

Mutation Information

Mutation Site	R277K
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	31943114
Published Year	2020
Journal	Nucleic acids research
Title	Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase.
Author	Nguyen PDM,Zheng J,Gremminger TJ,Qiu L,Zhang D,Tuske S,Lange MJ,Griffin PR,Arnold E,Chen SJ,Zou X,Heng X,Burke DH
Evidence	Protection at peptides covering position 277 was observed in both complexes but were notably were higher in RT-70.05core2 than in RT-148.1 complex (Supplementary Figure S9), consistent with the finding that R277K mutation abolished the inhibitory function of F1Pk aptamers but not UCAA aptamers.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation