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Mutation Information
|
Mutation Site
|
R486K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
10762559
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2000 |
|
Journal
|
The Journal of infectious diseases |
|
Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
|
Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
|
Evidence
|
The M125K mutant corresponds to a famciclovir-related mutation in the overlapping RT (H481Q), the G130R mutant to an unrelated mutation in the RT (R486K), and the C138Y to a silent mutation in the RT (L499L
|
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HBV Mutation Detail Information